The History of Sleeping Pills

Sleepwell / Sleeping Pills / The History of Sleeping Pills

BC to 19th century

From antiquity until the latter part of the 19^th century, alcohol and opium along with cannabis, valerian, and other ancient herbal remedies are used regularly to induce sleep.

Late 19th century

Chloral hydrate and various bromide salts quickly gain popularity. Careful attention to dose is paramount, especially with bromides, due to the risk of overdose with small dosing errors. Chloral hydrate risks (dependence, overdose toxicity, and kidney, heart, and liver damage) are slow to be recognized.

Early 20th century

Phenobarbital and other barbiturates are quickly adopted as “safer” alternative to bromides. However, their problems of addiction, withdrawal, and overdose toxicity are quickly recognized. Marilyn Monroe’s fatal overdose involved chloral hydrate and pentobarbital.

1960s: Benzos

With better safety and decades of intense marketing, the benzodiazepines transform sedative use. They, however, do not solve the problems of waning effectiveness, dependence, and withdrawal. Widespread use in older people causes serious problems, including injuries and memory problems.

Early 2000s

New “z-drugs” that work like benzodiazepines become the #1 class of sleeping pills. History repeats itself. Intense marketing, widespread use, and same pharmacological effects lead to dependence, withdrawal, injuries, memory problems, and limited effectiveness.

2010+: casting a wide net

Use of sedating antidepressants (doxepin, trazodone) and antipsychotics (quetiapine) for insomnia jumps up. Many try melatonin, a chemical made by the brain that signals nightfall. Manufacturers patent and develop a new generation of sleeping pills. Efforts to reduce sleeping pill use push ahead.